Reducing Risk Early: The Importance of Structural Liabilities, PAINS Analysis, and ADME Profiling in Lead Selection
Hit to lead services play a pivotal role in shaping the success of early-stage drug discovery. At this critical transition point—between initial hit identification and the emergence of high-quality lead candidates—researchers must rapidly eliminate compounds that look promising in assays but are destined to fail in preclinical or clinical development. Early risk reduction is not … Read more